Author/Editor		Portal, Edward; Descours, Ghislaine; Ginevra, Christophe; Mentasti, Massimo; Keše, Darja
Title		Legionella antibiotic susceptibility testing
Type		članek
Vol. and No.		Letnik 76, št. 5
Publication year		2021
Volume		str. 1113-1116
ISSN		0305-7453 - Journal of antimicrobial chemotherapy
Language		eng
Abstract		Legionella pneumophila, a Gram-negative bacillus, is the causative agent of Legionnaire's disease, a form of severe community-acquired pneumonia. Infection can have high morbidity, with a high proportion of patients requiring ICU admission, and up to 10% mortality, which is exacerbated by the lack of efficacy of typical empirical antibiotic therapy against Legionella spp. The fastidious nature of the entire Legionellaceae family historically required inclusion of activated charcoal in the solid medium to remove growth inhibitors, which inherently interferes with accurate antimicrobial susceptibility determination, an acknowledged methodological shortfall, now rectified by a new solid medium that gives results comparable to those of microbroth dilution. Here, as an international Legionella community (with authors representing various international reference laboratories, countries and clinical stakeholders for diagnosis and treatment of legionellosis), we set out recommendations for the standardization of antimicrobial susceptibility testing methods, guidelines and reference strains to facilitate an improved era of antibiotic resistance determination.
Keywords		Legionella pneumophila treatment of legionellosis recommendations for the standardization Legionella pneumophila zdravljenje legioneloze priporočila za standardizacijo