Author/Editor		Tóthová, Zuzana; Šemeláková, Martina; Solárová, Zuzana; Tomc, Jana; Debeljak, Nataša; Solár, Peter
Title		The role of PI3K/AKT and MAPK signaling pathways inerythropoietin signalization
Type		članek
Vol. and No.		Letnik 22, št. 14
Publication year		2021
Volume		str. 1-14
ISSN		1422-0067 - International journal of molecular sciences
Language		eng
Abstract		Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on varioustypes of cells and tissues. EPO and its receptor EPOR trigger signaling cascades JAK2/STAT5,MAPK, and PI3K/AKT that are interconnected and irreplaceable for cell survival. In this article, wedescribe the role of the MAPK and PI3K/AKT signaling pathways during red blood cell formationas well as in non-hematopoietic tissues and tumor cells. Although the central framework of thesepathways is similar for most of cell types, there are some stage-specific, tissue, and cell-lineagedifferences. We summarize the current state of research in this field, highlight the novel members ofEPO-induced PI3K and MAPK signaling, and in this respect also the differences between erythroidand non-erythroid cells.
Keywords		eritropoetin PI3K MAPK erythropoietin PI3K MAPK