Author/Editor		Nguyen, Dung; Simmonds, Peter; Steenhuis, Maurice; Wouters, Elise; Desmecht, Daniel; Garigliany, Mutien; Romano, Marta; Barbezange, Cyril; Resman Rus, Katarina; Avšič-Županc, Tatjana
Title		SARS-CoV-2 neutralising antibody testing in Europe
Type		članek
Vol. and No.		Letnik 26, št. 27
Publication year		2021
Volume		str. 1-6
ISSN		1560-7917 - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
Language		eng
Abstract		We compared the performance of SARS-CoV-2 neutralising antibody testing between 12 European laboratories involved in convalescent plasma trials. Raw titres differed almost 100-fold differences between laboratories when blind-testing 15 plasma samples. Calibration of titres in relation to the reference reagent and standard curve obtained by testing a dilution series reduced the inter-laboratory variability ca 10-fold. The harmonisation of neutralising antibody quantification is a vital step towards determining the protective and therapeutic levels of neutralising antibodies.
Keywords		COVID-19 neutralising antibody testing convalescent plasma COVID-19 testiranje nevtralizirajočih protiteles rekonvalescentna plazma