Author/Editor		Redenšek, Sara; Dolžan, Vita
Title		Principi farmakogenetike - od genetske variabilnosti do terapevtskih priporočil
Translated title		Principles of pharmacogenetics - from genetic variability to therapeutic recommendations
Type		članek
Vol. and No.		Letnik 72, št. 2
Publication year		2021
Volume		str. 90-99
ISSN		0014-8229 - Farmacevtski vestnik : strokovno glasilo slovenske farmacije
Language		slv
Abstract		It is estimated that 20 to 30% of variability in drug response in terms of efficacy and occurrence of adverse events is attributed to genetic variability in metabolic enzymes, transporters and drug targets. Various pharmacogenetic studies have already been performed and pharmacogenetic recommendations for 112 gene-drug pairs have already been proposed based on their results. The majority of studies have evaluated individual gene-drug pairs, but lately prospective studies based on preemptive pharmacogenetic testing have been undertaken. A part of such study named PREPARE is currently ongoing in Slovenia. There are 13 pharmacogenes with 48 genetic variants and 40 index drugs included in the study. The main goal of this study is to explore whether treatment according to the pharmacogenetic guidelines is safer, financially more efficient and increases the quality of patient's life more compared to the treatment according to the regular guidelines.
Keywords		k posamezniku usmerjena medicina farmakogenetska priporočila polimorfizem posameznega nukleotida personalised medicine pharmacogenetic recommendations single nucleotide polymorphism