Author/Editor		Ratoša, Ivica; Plavc, Gaber; Pišlar, Nina; Žagar, Tina; Perhavec, Andraž; Franco, Pierfrancesco
Title		Improved survival after breast-conserving therapy compared with mastectomy in stage I-IIA breast cancer
Type		članek
Vol. and No.		Letnik 13, št. 16
Publication year		2021
Volume		str. 4044-1-4044-15
ISSN		2072-6694 - Cancers
Language		eng
Abstract		In the current study, we sought to compare survival outcomes after breast-conserving therapy (BCT) or mastectomy alone in patients with stage I-IIA breast cancer, whose tumors are typically suitable for both locoregional treatments. The study cohort consisted of 1360 patients with stage I-IIA (T1%2N0 or T0%1N1) breast cancer diagnosed between 2001 and 2013 and treated with either BCT (n = 1021, 75.1%) or mastectomy alone (n = 339, 24.9%). Median follow-ups for disease-free survival (DFS) and overall survival (OS) were 6.9 years (range, 0.3%15.9) and 7.5 years (range, 0.2%25.9), respectively. Fifteen (1.1%), 14 (1.0%) and 48 (3.5%) patients experienced local, regional, and distant relapse, respectively. For the whole cohort of patients, the estimated 5-year DFS and OS were 96% and 97%, respectively. After stratification based on the type of local treatment, the estimated 5-year DFS for BCT was 97%, while it was 91% (p < 0.001) for mastectomy-only treatment. Inverse probability of treatment weighting matching based on confounding confirmed that mastectomy was associated with worse DFS (HR 2.839, 95% CI 1.760%4.579, p < 0.0001), but not with OS (HR 1.455, 95% CI 0.844%2.511, p = 0.177). In our study, BCT was shown to have improved disease-specific outcomes compared to mastectomy alone, emphasizing the important role of adjuvant treatments, including postoperative radiation therapy, in patients with early-stage breast cancer at diagnosis.
Keywords		zgodnji rak dojke rak dojke mastektomija radioterapija early-stage breast cancer breast cancer mastectomy radiation therapy