Author/Editor		Mironov, Alexander A.; Mironov, Anna; Derganc, Jure; Beznoussenko, Galina V
Title		Membrane curvature, trans-membrane area asymmetry, budding, fission and organelle geometry
Type		članek
Vol. and No.		Letnik 21, št. 20
Publication year		2020
Volume		str. 1-19
ISSN		1422-0067 - International journal of molecular sciences
Language		eng
Abstract		In biology, the modern scientific fashion is to mostly study proteins. Much less attention is paid to lipids. However, lipids themselves are extremely important for the formation and functioning of cellular membrane organelles. Here, the role of the geometry of the lipid bilayer in regulation of organelle shape is analyzed. It is proposed that during rapid shape transition, the number of lipid heads and their size (i.e., due to the change in lipid head charge) inside lipid leaflets modulates the geometrical properties of organelles, in particular their membrane curvature. Insertion of proteins into a lipid bilayer and the shape of protein trans-membrane domains also affect the trans-membrane asymmetry between surface areas of luminal and cytosol leaflets of the membrane. In the cases where lipid molecules with a specific shape are not predominant, the shape of lipids (cylindrical, conical, or wedge-like) is less important for the regulation of membrane curvature, due to the flexibility of their acyl chains and their high ability to diffuse.
Keywords		zlitje mitohondrijev asimetrija transmembranskega območja cepitev membrane mitochondria fusion trans-membrane area asymmetry membrane fission