Author/Editor		Jan, J; Logar, B; Jan, J
Title		Tissue distribution of co-planar and non-planar tetra- and hexa- chlorobiphenyl isomers in guinea pigs after oral ingestion
Type		članek
Source		Bull Environ Contam Toxicol
Vol. and No.		Letnik 56
Publication year		1996
Volume		str. 375-80
Language		eng
Abstract		Food ingestion is the most important route for the uptake of lipophilic organochlorine contaminants. Uptake and transfer of the contaminants from the digestive tract to target organs can be used for risk evaluation. The ioconcentration and migration of polychlorobiphenyls (PBCs) is highly structure - dependent (Safe 1989). Bioconcentration is correlated with lipophilicity on the basis ofthe n-octanol/water partition coefficient in its ogarithmic form - logKnow (McLachlan 1993; Gobas et al. 1994). However, some factors e.g. diffusion through cell membranes, accumulation in specific organs and tissues, uptake and depuration kinetics and metabolism can also influcence the bioconcentration (Franke et al. 1994). Individual PCB compounds of commercial PCB reparation are taken up by organisms to markedly different extents (Borlakoglu et al. 1991; Storrhansen and Spliid 1993; Bernhoft and Skaare 1994; Nims et al. 1994) Ness et al. 1994). Until now little is known about the distribution of non-planer and co-planer PCBs in different tissues. Co-planer PCBs have dioxin - like toxicity. The purpose of this study was to examine differences in the bioconcentration of two pairs of tetra- and hexa- hlorobiphenyls, corresponding to the co-planer and non-planer conformations, from the digestive tract and their distribution in different tissues of guinea pigs.
Descriptors		FOOD CONTAMINATION POLYCHLORINATED BIPHENYLS GUINEA PIGS ANIMALS, LABORATORY