Author/Editor		Vervaet, Benjamin A.; Nast, Cynthia C.; Schreurs, Gerd; Jayasumana, Channa; Herath, Chula; Kojc, Nika; De Broe, Marc E.
Title		Chronic interstitial nephritis in agricultural communities
Type		članek
Vol. and No.		Letnik 17, št. suppl.
Publication year		2021
Volume		str. 45-50
ISSN		1769-7255 - Néphrologie & thérapeutique
Language		eng
Abstract		Chronic interstitial nephritis in agricultural communities is a devastating kidney disease with a globally increasing prevalence. Its cause is unknown. Two predominant etiologies are hypothesised: recurrent episodes of dehydration and exposure to environmental toxins, such as agrochemicals and metals. In this review, we summarise arguments on: 1) why heat stress/dehydration is an unlikely cause of this disease and 2) why chronic interstitial nephritis in agricultural communities is to be considered a toxin-induced nephropathy. Mechanistically, we provide arguments for a putative role of pesticides on the one hand, and the calcineurin pathway on the other hand, both of which require further investigation. Finally, we summarise several important perspectives for research on chronic interstitial nephritis in agricultural communities.
Keywords		kronična ledvična bolezen zaviranje kalcinevrina nefrotoksičnost chronic kidney disease calcineurin inhibition nephrotoxicity