| Author/Editor | Salobir-Pajnič, B | |
| Title | Koagulacija in fibrinoliza pri mladih ženskah, ki so prebolele trombembolijsko bolezen | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 1995 | |
| Volume | str. 72 | |
| Language | slo | |
| Abstract | Imbalance between coagulation and fibrinolytic system could play an important role in developement of atherothrombotic diseases. Little is known about these changes in women who suffered atherothrombotic events in the reproductive period. Therefore, we decided to investigate coagulation and fibrinolytic parameters and their associations with already known risk factors in women, who suffered acute myocardial infarction (AMI) (N=22), ischaemic cerebrovascular stroke (ICV) (N=16) or venus thrombembolisms (VTE) (N=30) in the reproductive period. In 16 women the only known trigger for VTE was use of oral contraceptive pills an in 14 women VTE was idiopathic. Patients were included in the study half to six years after the event. In the control group 52 age matched women, who were hospitalized in the same period as patients because of other disease, were included. Besides already known risk factors as blood lipids, glucose and insulin we measured lipoprotein(a) (Lp(a)). We performed screening coagulation test, including fibrinogen, antithrombin III and protein C activity and resistance to activated protein C. Fibrinolytic activity was measured with euglobulin clot lysis time (ECLT), activity and antigen of tissue type plasminogen activator (t-PA) and its fast inhibitor (PAI-1). Intravascular fibrin formation was determined by measuring D-dimers. We determined sedimentation rate and C-reactive protein to exclude acute inflammation. Antiphospholipid antibodies to cardiolipin and phosphatidylserine were measured as well. In the group of AMI besides known risk factors we found signifi cant changes in fibrinolytic system due to significantly higher t-PA antigen. The intravascular formation of fibrin was accelerated in associations with disturbed fibrinolysis. Correlations between fibrinolytic and some metabolic parameters known to be part of the syndrome X were significant and we concluded that changes in fibrinolytic system were part of this syndrome.(trunc.) | |
| Descriptors | THROMBOEMBOLISM BLOOD COAGULATION TESTS FIBRINOLYSIS CONTRACEPTIVES, ORAL, HORMONAL ADULT MYOCARDIAL INFARCTION THROMBOPHLEBITIS CEREBROVASCULAR DISORDERS |