| Author/Editor | Bratanič, B | |
| Title | Na eritrocite vezani bilirubin pri hiperbilirubinemičnih novorojencih | |
| Type | monografija | |
| Place | Zagreb | |
| Publisher | Medicinska fakulteta | |
| Publication year | 1995 | |
| Volume | str. 39 | |
| Language | slo | |
| Abstract | The hyperbilirubinemia could produce permanent damage to the central nervous system in newborns. The value of total serum bilirubin does not predict the danger of complications of hyperbilirubinemia sufficiently enough and renders clinical decisions for and gainst therapy very difficult. Therefore the erythrocyte bound bilirubin has been introduced as new method in 94 subsequently admitted newborn infants (21 preterm and 73 term infants), aged 5 days, who because of neonatal hyperbilirubinemia needed venous blood sampling for determination of total and directly reacting serum bilirubin. Method was introduced after the Bratlid and Kaufmann et al. This for us new laboratory test should indirectly indicate the amount of bilirubin that has been liberated from albumin molecules and became availabe for penetration of the cell membranes (erythrocyte and neuronal). Our orientational reference values (average erythrocyte bound bilirubin: 9.+-4,7, from 2.5 to 20 micromolmol/L, with average serum bilirubin: 218.3+-66.9, from 68.5 to 321.0 micromolmol/L) showed that 4.4 precent of the serum bilirubin became normally bound to the erythrocytes, which is in agreement with values published in the literature. Comparisons between term and preterm icteric infants showed significantly lower values of the albumin in preterm infants (33.9=-2.2, from 30 to 39 g/L; in term infants: 36.5=-3.7, from 29 to 46 g/L) and positive correlation between the serum bilirubin and the erythrocyte bound bilirubin. There was also positive correlation between the molar bilirubin/albumin ratio and the erythrocyte bo und bilirubin especially in term infants. The preterm infants had significantly more pathologic audiometry results (p less th.0.001). As an additional test the erythrocyte bound bilirubin could be helpful in the clinical decision making process in jaundiced newborn infants. Abstract truncated | |
| Descriptors | JAUNDICE, NEONATAL BILIRUBIN ERYTHROCYTES INFANT, NEWBORN INFANT, PREMATURE SERUM ALBUMIN AUDIOMETRY, EVOKED RESPONSE |