Author/Editor		Gužič, B
Title		Metabolični in fibrinolitični učinki ovsenih vlaken v prehrani pri koronarnih bolnikih s sladkorno boleznijo tip 2
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1995
Volume		str. 58
Language		slo
Abstract		The impairment of fibrinolysis through elevation of plasminogen activator inhibitor (PAI) activity could be associated with increased risk for ischaemic heart disease in patients with diabetes mellitus. One of the most important treatment strategy is appropriate diet with dietary fiber supplementation. Oat husk fiber has been shown to decrease normal PAI activity in 11 health volunteers. The aim of our study was to examine the influence of oat husk supplementation on fibrinolytic and metabolic variables in survivors of myocardial infarction with diabetes mellitus type 2, who have elevated PAI activity. 43 survivors of myocardial infarction with diabetes type 2 (35 males and 7 females, aged 51 to 78 years, mean age 63.9+-6.6, with body mass index BMI 29.6+-4.1 kg/square meter) were randomly assigned to two groups of comparable age and BMI. Patients from treated group consumed 5.4 g of oat husk fiber tablets in addition to their regular diet for 6 weeks (adaptation period). Patients in control group maintained their regular diet only. Blood samples were collected at the entry of the study, after 6 weeks, after 4 weeks and after 4 weeks of washout period. We measured total and HDL cholesterol, triglycerides, serum glucose, insulin, glycosilated haemoglobin, lipoprotein(a), plasma tissue plasminogen activator (t-PA) activity and antigen, PAI activity and antigen, plasminogen activity, fibrinogen and euglobulin clot lysis time. There were no significant differences in basal levels of BMI, PAI activity and antigen and t-PA activity and antigen between both groups. We did not demonstrate any significant change of PAI activity and antigen levels following the 4 weeks of 10.8 g husk fiber supplement per day. Oat husk tablets decreased LDL cholesterol levels (for 18 percent), the concomitant decrease in control group was lower (for 7 percent). There was an increase in HDL cholesterol in both groups during the study.(trunc.)
Descriptors		DIABETES MELLITUS, NON-INSULIN-DEPENDENT MYOCARDIAL INFARCTION DIETARY FIBER PLASMINOGEN ACTIVATORS ALTEPLASE OATS BODY MASS INDEX TRIGLYCERIDES BLOOD GLUCOSE INSULIN HEMOGLOBIN A, GLYCOSYLATED LIPOPROTEINS LIPOPROTEINS, HDL CHOLESTEROL PLASMINOGEN FIBRINOGEN CLOT RETRACTION ADULT