Author/Editor		Fakhr, Elham; Modic, Živa; Cid-Arregui, Angel
Title		Recent developments in immunotherapy of cancers caused by human papillomaviruses
Type		članek
Vol. and No.		, št. Vol. 163
Publication year		2020
Volume		str. 33-45
ISSN		1365-2567 - Immunology
Language		eng
Abstract		A subset of oncogenic human papillomaviruses (HPVs) is the main cause of genital cancers, most importantly cervical cancer and an increasing number of head and neck cancers. Despite the availability of prophylactic vaccines against the most prevalent oncogenic HPV types, HPV-induced malignancies are still a major health and economic burden. Besides conventional treatment with surgery, chemotherapy and radiation, immunotherapy is emerging as an efficient adjuvant option. Here, we review relevant studies and ongoing clinical trials using immune checkpoint inhibitors, therapeutic vaccines, gene editing approaches and adoptive T cell therapies, with special focus on engineered TCR T cells, which are showing encouraging results and could lead to significant improvement in the treatment of HPV+-infected cancer patients.
Keywords		HPV rak materničnega vratu humani papiloma virus imunoterapija cervical cancer human papillomavirus immunotherapy