| Author/Editor | Wimo, Anders; Belger, Mark; Bon, Jaka; Jessen, Frank; Dumas, Annette; Gregorič Kramberger, Milica; Jamilis, Laura; Johansson, Gunilla; Petek, Davorina | |
| Title | A cost-consequence analysis of different screening procedures in Alzheimer's disease | |
| Type | članek | |
| Vol. and No. | Letnik 83, št. 3 | |
| Publication year | 2021 | |
| Volume | str. 1149-1159 | |
| ISSN | 1387-2877 - Journal of Alzheimer's disease : JAD | |
| Language | eng | |
| Abstract | Background: For care planning and support, under-detection and late diagnosis of Alzheimer%s disease (AD) is a great challenge. Models of Patient-Engagement for Alzheimer%s Disease (MOPEAD) is an EU-funded project aiming at testing different strategies to improve this situation. Objective: To make a cost-consequence analysis of MOPEAD. Methods: Four screening strategies were tested in five countries (Germany, the Netherlands, Slovenia, Spain, and Sweden): 1) a web-approach; 2) Open-House initiative; 3) in primary care; and 4) by diabetes specialists. Persons-at-risk of AD in all strategies were offered referral to a hospital-based specialist. The primary health-economic outcome was the cost per true-positive case (TP) of AD from the screened population. Results: Of 2,847 screened persons, 1,121 screened positive (39%), 402 were evaluated at memory clinics (14%), and 236 got an AD diagnosis (8%). The cost per TP of those screened was D3,115 with the web-approach, D2,722 with the Open- House, D1,530 in primary care, and D1,190 by diabetes specialists. Sensitivity analyses that more likely reflect the real-world situation confirmed the results. The number-needed-to-screen was 30 with the web-approach, 8 with the Open-House and primary care, and 6 with the diabetes specialists. There were country differences in terms of screening rates, referrals to memory clinics, staff-types involved, and costs per TP. Conclusion: In primary care and by the diabetes specialist, the costs per TP/screened population were lowest, but the capacity of such settings to identify cases with AD-risk must be discussed. Hence new diagnostic strategies such as web-solutions and Open-House initiatives may be valuable after modifications. | |
| Keywords | Alzheimer's disease cost-consequence analysis cost analysis Alzheimerjeva bolezen analiza stroškov in posledic analiza stroškov |