Author/Editor		Csikós, Eszter; Horváth, Adrienn; Ács, Kamilla; Papp, Nóra; Balázs, Viktória Lilla; Sollner Dolenc, Marija; Kenda, Maša; Kočevar Glavač, Nina; Nagy, Milan; Protti, Michele
Title		Treatment of benign prostatic hyperplasia by natural drugs
Type		članek
Vol. and No.		Letnik 26, št. 23
Publication year		2021
Volume		str. 1-32
ISSN		1420-3049 - Molecules (Basel, Switzerland)
Language		eng
Abstract		Benign prostatic hyperplasia (BPH) is one of the most common urinary diseases affecting men, generally after the age of 50. The prevalence of this multifactorial disease increases with age. With aging, the plasma level of testosterone decreases, as well as the testosterone/estrogen ratio, resulting in increased estrogen activity, which may facilitate the hyperplasia of the prostate cells. Another theory focuses on dihydrotestosterone (DHT) and the activity of the enzyme 5[alpha]-reductase, which converts testosterone to DHT. In older men, the activity of this enzyme increases, leading to a decreased testosterone/DHT ratio. DHT may promote prostate cell growth, resulting in hyperplasia. Some medicinal plants and their compounds act by modulating this enzyme, and have the above-mentioned targets. This review focuses on herbal drugs that are most widely used in the treatment of BPH, including pumpkin seed, willow herb, tomato, maritime pine bark, Pygeum africanum bark, rye pollen, saw palmetto fruit, and nettle root, highlighting the latest results of preclinical and clinical studies, as well as safety issues. In addition, the pharmaceutical care and other therapeutic options of BPH, including pharmacotherapy and surgical options, are discussed, summarizing and comparing the advantages and disadvantages of each therapy.
Descriptors		Benigna prostatična hiperplazija Zdravilne rastline Fitoterapija
Keywords		predklinične študije klinična učinkovitost varnostne težave benign prostatic hyperplasia medicinal plants phytotherapy saw palmetto preclinical studies clinical efficacy safety issues