Author/Editor		Manferdelli, Giorgio; Narang, Benjamin J.; Poussel, Mathias; Osredkar, Damjan; Millet, Grégoire P.; Debevec, Tadej
Title		Long-term effects of prematurity on resting ventilatory response to hypercapnia
Type		članek
Vol. and No.		Letnik 22, št. 4
Publication year		2021
Volume		str. 420-425
ISSN		1557-8682 - High altitude medicine & biology
Language		eng
Abstract		Background: This study investigated the resting ventilatory response to hypercapnia in prematurely born adults. Materials and Methods: Seventeen preterm and fourteen full-term adults were exposed to normoxic hypercapnia (two 5-minute periods at 3% and 6% carbon dioxide [CO2] interspersed by 5-minute in normoxia). Pulmonary ventilation () and end-tidal partial pressure of CO2 (Petco2) were measured continuously. Results: No difference in lung function was observed between preterm and full-term adults. Petco2 was lower in preterm than in full-term adults (p < 0.05) during normoxia. During exposure to 3% CO2, both and Petco2 increased in a similar way in preterm and full-term adults. However, at the end of the 6% CO2 period, there was a significantly higher in preterm compared with full-term adults (30.2 ± 7.5 vs. 23.7 ± 4.5 L/min, p < 0.0001), whereas no difference was observed for Petco2 (46.9 ± 2.1 vs. 50.6 ± 2.1 L/min, p = 0.99). Breath frequency was higher in preterm than in full-term adults (17.9 ± 4.0 vs. 12.8 ± 3.5 b/min, p < 0.01) during 6% CO2 exposure. Conclusions: Although data suggest that prematurity results in resting hypocapnia, the exact underlying mechanisms remain to be elucidated. Moreover, preterm adults seem to have increased chemosensitivity to hypercapnia.
Keywords		preterm hypercapnia ventilatory response nedonošenček hiperkapnija ventilacijski odziv