Author/Editor		Roškar, Luka; Roškar, Irena; Lanišnik-Rižner, Tea; Smrkolj, Špela
Title		Diagnostic and therapeutic values of angiogenic factors in endometrial cancer
Type		članek
Vol. and No.		Letnik 12, št. 1
Publication year		2022
Volume		str. [1]-14
ISSN		2218-273X - Biomolecules
Language		eng
Abstract		Endometrial cancer (EC) is the most frequent gynecological malignancy in developed countries and requires a relatively invasive diagnostic evaluation and operative therapy as the primary therapeutic approach. Angiogenesis is one of the main processes needed for cancer growth and spread. The production of angiogenic factors (AFs) appears early in the process of carcinogenesis. The detection of AFs in plasma and tissue and a better understanding of the angiogenic properties of EC may contribute not only to earlier but also more specific diagnosis and consequently tailored and individual therapeutic approaches. AFs and their receptors also have high potential as binding sites for targeted cancer therapy. In this review, we discuss angiogenesis in EC and the characteristics of the AFs that most contribute to angiogenesis in EC. We also highlight therapeutic strategies that target angiogenesis as potential EC therapy.
Keywords		endometrial cancer angiogenesis biomarkers rak endometrija angiogeneza biomarkerji