Author/Editor		Charalampidi, Aggeliki; Kordou, Zoe; Tsermpini, Evangelia Erini; Bosganas, Panagiotis; Chantratita, Wasun; Fukunaga, Koya; Mushiroda, Taisei; Patrinos, George P.; Koromina, Maria
Title		Pharmacogenomics variants are associated with BMI differences between individuals with bipolar and other psychiatric disorders
Type		članek
Vol. and No.		Letnik 22, št. 12
Publication year		2021
Volume		str. 749-760
ISSN		1462-2416 - Pharmacogenomics
Language		eng
Abstract		Aim: Regardless of the plethora of next-generation sequencing studies in the field of pharmacogenomics (PGx), the potential effect of covariate variables on PGx response within deeply phenotyped cohorts remains unexplored. Materials & methods: We explored with advanced statistical methods the potential influence of BMI, as a covariate variable, on PGx response in a Greek cohort with psychiatric disorders. Results: Nine PGx variants within UGT1A6, SLC22A4, GSTP1, CYP4B1, CES1, SLC29A3 and DPYD were associated with altered BMI in different psychiatric disorder groups. Carriers of rs2070959 (UGT1A6), rs199861210 (SLC29A3) and rs2297595 (DPYD) were also characterized by significant changes in the mean BMI, depending on the presence of psychiatric disorders. Conclusion: Specific PGx variants are significantly associated with BMI in a Greek cohort with psychiatric disorders.
Keywords		body mass index pharmacogenes psychiatric diseases indeks telesne mase farmakogeni psihiatrične bolezni