Author/Editor		Tsermpini, Evangelia Erini; Zhang, Yanfei; Niola, Paola; Chillotti, Caterina; Ardau, Raffaella; Bocchetta, Alberto; Patrinos, George P.; Del Zompo, Maria; Severino, Giovanni; Lee, Ming Ta Michael; Squassina, Alessio
Title		Pharmacogenetics of lithium effects on glomerular function in bipolar disorder patients under chronic lithium treatment
Type		članek
Vol. and No.		, št. Vol. 638
Publication year		2017
Volume		str. 1-4
ISSN		0304-3940 - Neuroscience letters
Language		eng
Abstract		Bipolar disorder (BD) is a psychiatric disease characterized by alternating episodes of mania and depression. Lithium (Li) represents the mainstay treatment for BD, although a significant proportion of patients shows insufficient or no response. Li is also associated with potentially severe side effects, including renal effects. Several studies reported that Li may induce reduction of glomerular filtration rate (GFR) in patients under long-term treatment. The biological systems and the genetic factors involved in susceptibility to Li-induced renal-side effects have been scarcely explored. The aim of our study was to test the contribution of putatively risk genetic variants in Li-induced reduction in estimated GFR (eGFR) in BD patients under long-term Li treatment. Tag SNPs, located in genes previously shown to be associated with kidney dysfunction or Li mechanism of action, were selected and genotyped in a sample of 70 BD patients of Sardinian origin. SNP rs378448, located in Acid Sensing Ion Channel Neurona-1 (ACCN1) gene, showed a significant interaction with duration of Li treatment on eGFR (F2=3.623, p=0.033). Our preliminary findings suggest that rs378448 could predispose BD subjects to a detrimental effect of chronic Li treatment on kidney functioning.
Keywords		bipolar disorder adverse drug reaction genetic variation bipolarna motnja neželeni učinek zdravila genetske variacije