Author/Editor		Deuning-Smit, Esther; Custers, José A. E.; Miroševič, Špela; Takes, Robert P.; Jansen, Femke; Langendijk, Johannes A.; Terhaard, Chris H. J.; Baatenburg de Jong, Robert J.; Leemans, C. Renè; Smit, Johannes H.
Title		Prospective longitudinal study on fear of cancer recurrence in patients newly diagnosed with head and neck cancer
Type		članek
Publication year		2022
Volume		str. str.
ISSN		1043-3074 - Head and neck
Language		eng
Abstract		The incidence and risk factors for the development of high-grade dysplasia (HG-D) and laryngeal squamous cell carcinoma (LSCC) were assessed in patients with laryngeal squamous cell papillomas (LSP). Methods Clinical data, human papillomaviruses (HPV) typing, HPV E6/E7 mRNA in situ hybridization, and sequencing of host genes in LSP biopsies of 163 patients were analyzed. Results Progression to HG-D and LSCC was identified in 21.5% and 4.3% of LSP patients, respectively. A more advanced age at LSP onset and lack of HPV infection were detected as risk factors for the development of HG-D and LSCC (P <.05). The identification of HG-D was associated with its progression to LSCC (P <.05). Host gene mutations were identified in 3 of 7 patients with LSCC. Conclusions The histological monitoring of LSP and HPV typing are necessary for early detection of epithelial changes. Further research is needed to elucidate the role of host gene mutations in LSCC transformation.
Keywords		strah pred ponovitvijo raka analiza rasti latentnega razreda rak glave in vratu fear of cancer recurrence latent class growth analysis head and neck cancer