Author/Editor		Mendenhall, William M.; Strojan, Primož; Lee, Anne W. M.; Rinaldo, Alessandra; Eisbruch, Avraham; Ng, Wai Tong; Smee, Robert; Ferlito, Alfio
Title		Radiotherapy in the management of glottic squamous cell carcinoma
Type		članek
Vol. and No.		Letnik 42, št. 12
Publication year		2020
Volume		str. 3558-3567
ISSN		1043-3074 - Head and neck
Language		eng
Abstract		Our purpose is to review the role radiotherapy (RT) in the treatment of glottic squamous cell carcinoma (SCC). Methods: A concise review of the pertinent literature. Results: RT cure rates are Tis- T1N0, 90% to 95%; T2N0, 70% to 80%; low-volume T3-T4a, 65% to 70%. Concomitant cisplatin is given for T3-T4a SCCs. Severe complications occur in 1% to 2% for Tis-T2N0 and 10% for T3-T4a SCCs. Patients with high-volume T3-T4 SCCs undergo total laryngectomy, neck dissection, and postoperative RT. Those with positive margins and/or extranodal extension receive concomitant cisplatin. The likelihood of local-regional control at 5 years is 85% to 90%. Severe complications occur in 5% to 10%. Conclusions: RT is a good treatment option for patients with Tis-T2N0 and low-volume T3-T4a glottic SCCs. Patients with higher volume T3-T4 cancers are best treated with surgery and postoperative RT.
Keywords		ekstranodalna ekstenzija rak glave in vratu radioterapija ploščatocelični rak extranodal extension head and neck cancer squamous cell carcinoma