Author/Editor		Delić, Ratko; Štefanović, Mario; Krivec, Štefka; Weber, Vladimir; Koren, Jakob
Title		HE4 levels in uncomplicated pregnancies: are there any differences?
Type		članek
Vol. and No.		Letnik 35, št. 3
Publication year		2022
Volume		str. 610-612
ISSN		1476-7058 - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Language		eng
Abstract		Objective. The aim of our study was to evaluate HE4 serum concentrations throughout uncomplicated pregnancies in the absence of adnexal masses. Methods In a retrospectively designed, monocentric study (Department of Gynecology and Obstetrics, General Hospital Celje, Celje, Slovenia, EU), 229 women with uncomplicated pregnancies were included. HE4 levels were obtained and analyzed with regard to gestational age of pregnancy. Results. While having all HE4 levels within reference range, differences in mean concentrations between study groups were found be statistically significant (Group I, n = 22, <20 weeks of pregnancy, mean = 42.2 pmol/L; Group II, n = 40, pregnancies between 20‐34 weeks of pregnancy, mean = 43.6 pmol/L; Group III, n = 167, s34 weeks of pregnancy, mean = 57.5 pmol/L, p < .001). Conclusion. Our findings confirmed that HE4 levels in uncomplicated pregnancies are within reference range provided by manufacturer, however its serum concentration rises significantly in third trimester. The HE4 cutoff value (<140 pmol/L) used for nonpregnant women can be helpful in the evaluation of adnexal masses in pregnancy.
Descriptors		Pregnancy Epididymal secretory proteins Nosečnost Epididimalni sekretorni proteini