Author/Editor		Troha Gergeli, Anja; Škofljanec, Andreja; Neubauer, David; Paro Panjan, Darja; Kodrič, Jana; Osredkar, Damjan
Title		Prognostic value of various diagnostic methods for long-term outcome of newborns after hypoxic-ischemic encephalopathy treated with hypothermia
Type		članek
Vol. and No.		, št. Vol. 10
Publication year		2022
Volume		str. 1-9
ISSN		2296-2360
Language		eng
Abstract		Introduction: Prediction of outcome in newborns with hypoxic-ischemic encephalopathy (HIE) has been modulated by hypothermia treatment (HT). We assessed the predictive value of diagnostic methods commonly used in neonates with HIE for short-term neurodevelopmental outcome and long-term neurological outcome. Materials and Methods: This longitudinal cohort study followed up 50 term newborns who underwent HT after HIE between July 2006 and August 2015, until preschool age. We estimated sensitivity and specificity for short-term neurodevelopmental outcome at 18 months and long-term neurological outcome at five years based on Amiel-Tison Neurological Assessment (ATNA), electroencephalography (EEG), and magnetic resonance imaging (MRI) performed in the neonatal period. Results: The accuracy of all neonatal methods tested was higher for long-term neurological outcome compared to the predictive accuracy for short-term neurodevelopmental outcome at 18‐24 months. Sensitivity and specificity in predicting unfavorable long-term neurological outcome were: MRI (sensitivity 1.0 [95%CI 0.96‐1.0]; specificity 0.91 [95%CI 0.86‐1.0]), EEG (sensitivity 0.94 [95%CI 0.71‐1.0]; specificity 1.0 [95% CI 0.89‐1.0]), and ATNA (sensitivity 0.94 [95%CI 0.71‐1.0]; specificity 0.91 [95%CI 0.76‐0.98]). Conclusion: MRI is a powerful predictor of long-term neurological outcome when performed in the first week after HIE in HT treated infants, as are EEG and ATNA performed in the second or third week postnatally.
Keywords		hipoksično-ishemična encefalopatija perinatalna asfiksija zdravljenje hipotermije hypoxic-ischemic encephalopathy perinatal asphyxia hypothermia treatment