Author/Editor		Stergar, Janja; Gradišnik, Lidija; Velnar, Tomaž; Maver, Uroš
Title		Intervertebral disc tissue engineering
Type		članek
Vol. and No.		Letnik 19, št. 2
Publication year		2019
Volume		str. 130-137
ISSN		1840-4812 - Bosnian journal of basic medical sciences / Udruzenje basicnih mediciniskih znanosti = Association of Basic Medical Sciences
Language		eng
Abstract		Intervertebral disc (IVD) degeneration (IDD) is associated with low back pain and significantly affects the patient's quality of life. Degeneration of the IVD alters disk height and the mechanics of the spine, leading to chronic segmental spinal instability. The pathophysiology of IVD disease is still not well understood. Current therapies for IDD include conservative and invasive approaches, but none of those treatments are able to restore the disc structure and function. Recently, tissue engineering techniques emerged as a possible approach to treat IDD, by replacing a damaged IVD with scaffolds and appropriate cells. Advances in manufacturing techniques, material processing and development, surface functionalization, drug delivery systems and cell incorporation furthered the development of tissue engineering therapies. In this review, biomaterial scaffolds and cell-based therapies for IVD regeneration are briefly discussed.
Keywords		intervertebral disc IVD cell-based therapies scaffolds tissue engineering IVD degeneration IDD