Author/Editor		Onyango, Isaac G.; Bennett, James P.; Stokin, Gorazd Bernard
Title		Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases
Type		članek
Vol. and No.		Letnik 16, št. 8
Publication year		2021
Volume		str. 1467-1482
ISSN		1673-5374 - Neural Regeneration Research
Language		eng
Abstract		Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are a heterogeneous group of debilitating disorders with multifactorial etiologies and pathogeneses that manifest distinct molecular mechanisms and clinical manifestations with abnormal protein dynamics and impaired bioenergetics. Mitochondrial dysfunction is emerging as an important feature in the etiopathogenesis of these age-related neurodegenerative diseases. The prevalence and incidence of these diseases is on the rise with the increasing global population and average lifespan. Although many therapeutic approaches have been tested, there are currently no effective treatment routes for the prevention or cure of these diseases. We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases.
Keywords		Alzheimer’s disease Huntington’s disease Parkinson’s disease Alzheimerjeva bolezen Huntingtonova bolezen Parkinsonova bolezen