| Author/Editor | Krell-Roesch, Janina; Pink, Anna; Roberts, Rosebud O.; Stokin, Gorazd Bernard; Mielke, Michelle M.; Spangehl, Kathleen A.; Bartley, Maired M.; Knopman, David S.; Christianson, Teresa J.; Petersen, Ronald C.; Geda, Yonas Endale | |
| Title | Timing of physical activity, apolipoprotein E (APOE) ε4 genotype, and the risk of incident mild cognitive impairment | |
| Type | članek | |
| Vol. and No. | Letnik 64, št. 12 | |
| Publication year | 2016 | |
| Volume | str. 2479-2486 | |
| ISSN | 0002-8614 - Journal of the American Geriatrics Society | |
| Language | eng | |
| Abstract | Objectives: To investigate the timing (mid- vs late life) of physical activity, apolipoprotein (APO)E ε4, and risk of incident mild cognitive impairment (MCI). Design: Prospective cohort study. Setting: Mayo Clinic Study of Aging (Olmsted County, MN). Participants: Cognitively normal elderly adults (N = 1,830, median age 78, 50.2% female). Measurements: Light, moderate, and vigorous physical activities in mid- and late life were assessed using a validated questionnaire. An expert consensus panel measured MCI based on published criteria. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) with age as a time scale after adjusting for sex, education, medical comorbidity, and depression. Results: Light (HR = 0.58, 95% CI = 0.43-0.79) and vigorous (HR = 0.78, 95% CI = 0.63-0.97) physical activity in midlife were associated with lower risk of incident MCI. The association between moderate activity and incident MCI was not significant (HR = 0.85, 95% CI = 0.67-1.09). In late life, light (HR = 0.75, 95% CI = 0.58-0.97) and moderate (HR = 0.81, 95% CI = 0.66-0.99) but not vigorous physical activity were associated with lower risk of incident MCI. A synergistic interaction was also observed between mid- and late-life activity in reducing risk of incident MCI. Furthermore, APOE ε4 carriers who did not exercise had a higher risk of incident MCI than noncarriers who reported physical activity. Conclusion: Physical activity reduced the risk of incident MCI. Exercising in mid- and late life had an additive synergistic interaction in reducing the risk of MCI. | |
| Keywords | blage kognitivne motnje telesna aktivnost zlom kolka APOE e4 mild cognitive impairment physical activity APOE e4 |