Author/Editor		Gkoutos, Georgios V.; Mallon, Ann-Marie; Blake, A.; Greenaway, Simon; Hancock, John M.; Davidson, D.
Title		Ontologies for the description of mouse phenotypes
Type		članek
Vol. and No.		Letnik 5, št. 6/7
Publication year		2004
Volume		str. 545-551
ISSN		1531-6912 - Comparative and functional genomics
Language		eng
Abstract		Ontologies are becoming increasingly important for the efficient storage, retrieval and mining of biological data. The description of phenotypes using ontologies is a particularly complex problem. We outline a schema that can be used to describe phenotypes by combining orthologous axiomatic ontologies. We also describe tools for storing, browsing and searching such complex ontologies. Central to this approach is that assays (protocols for measuring phenotypic characters) describe what has been measured as well as how this was done, allowing assays to link individual organisms to ontologies describing phenotypes. We have evaluated this approach by automatically annotating data on 600,000 mutant mice phenotypes using the SHIRPA protocol. We believe this approach will enable the flexible, extensible and detailed description of phenotypes from any organism.
Keywords		ontologija fenotipa opis fenotipa bioinformatika phenotype ontology phenotype description bioinformatics