Author/Editor		Hancock, John M.; Simon, Michelle M
Title		Simple sequence repeats in proteins and their significance for network evolution
Type		članek
Vol. and No.		Letnik 345, št. 1
Publication year		2005
Volume		str. 113-118
ISSN		0378-1119 - Gene
Language		eng
Abstract		Only 5-6% of mammalian genomes are genes; the remainders are made up primarily of transposable elements and different types of simple sequence repeat (SSRs) (micro- and minisatellites and cryptic repeats), which tend to accumulate in organisms with larger genomes. SSRs are also found at the level of protein sequences and may or may not be encoded by SSRs at the DNA sequence level. Studies of proteins containing SSRs indicate that they tend to belong to particular functional classes, particularly transcription factors and protein kinases. Protein SSRs coded for by pure codon repeats evolve rapidly while those encoded by mixtures of codons evolve slowly. We outline a conceptualization of how protein SSRs may arise and become fixed in proteins during evolution, and suggest that emergence and change in length of protein SSRs may affect the topology of protein interaction networks.
Keywords		proteins simple sequence repeats genomes beljakovine enostavne ponovitve zaporedja genomi