Author/Editor		Hancock, John M.
Title		Gene factories, microfunctionalization and the evolution of gene families
Type		članek
Vol. and No.		Letnik 21, št. 11
Publication year		2005
Volume		str. 591-595
ISSN		0168-9525 - Trends in genetics : TIG
Language		eng
Abstract		Gene duplication has long been considered an important force in genome evolution. In this article, I consider families of tandemly duplicated genes that show 'microfunctionalization' - genes encoding similar proteins with subtly different functions, such as olfactory receptors. I discuss the genomic processes giving rise to such microfunctionalized gene families and suggest that, like sites of chromosomal rearrangement and breakage, they are associated with relatively high concentrations of repetitive elements. I suggest that microfunctionalized gene families arise within gene factories: genomic regions rich in repetitive elements that undergo increased levels of unequal crossing-over.
Keywords		genome evolution gene duplication microfunctionalized gene families evolucija genomov podvajanje genov mikrofunkcionalizirane genske družine