Author/Editor		Hancock, John M.; Mallon, Ann-Marie; Beck, Tim; Gkoutos, Georgios V.; Mungall, Chris; Schofield, Paul N.
Title		Mouse, man, and meaning
Type		članek
Vol. and No.		Letnik 20, št. 8
Publication year		2009
Volume		str. 457-461
ISSN		0938-8990 - Mammalian genome : official journal of the International Mammalian Genome Society
Language		eng
Abstract		Now that the laboratory mouse genome is sequenced and the annotation of its gene content is improving, the next major challenge is the annotation of the phenotypic associations of mouse genes. This requires the development of systematic phenotyping pipelines that use standardized phenotyping procedures which allow comparison across laboratories. It also requires the development of a sophisticated informatics infrastructure for the description and interchange of phenotype data. Here we focus on the current state of the art in the description of data produced by systematic phenotyping approaches using ontologies, in particular, the EQ (Entity-Quality) approach, and what developments are required to facilitate the linking of phenotypic descriptions of mutant mice to human diseases.
Keywords		fenotipizacija informacijska infrastruktura ontologija phenotyping informatics infrastructure ontology