Author/Editor		Hancock, John M.
Title		Mouse genetic and phenotypic resources as tools for human genetics
Type		članek
Source		In: Encyclopedia of life sciences [Chichester] : Wiley InterScience
Publication year		2013
Volume		str. 1-10
Language		eng
Abstract		The laboratory mouse community provides a rich set of data and material resources for scientists. The primary one is the Mouse Genome Informatics resource at the Jackson Laboratory (JL), supplemented by other resources at the JL and elsewhere, including a rich variety of gene expression information often presented in the form of gene expression atlases. Ordering and distribution of mutant and inbred mouse strains is well organised via the International Mouse Strain Resource. Resources such as knockout embryonic stem cells from the International Knockout Mouse Consortium (IKMC) and other nontraditional genetic resources such as the Collaborative Cross, Diversity Outbred and Chromosome Substitution lines are also available via the web. Systematic phenotyping of mouse strains, in particular knockout strains from the IKMC, is a new and developing field with a developing informatics infrastructure, which uses new approaches to data representation via ontologies to integrate data across species and to human disease information.
Keywords		človeška genetika fenotipski viri mišji sevi human genetics phenotypic resources mouse strains