| Author/Editor | Edhemović, Ibrahim; Brecelj, Erik; Čemažar, Maja; Boc, Nina; Trotovšek, Blaž; Djokić, Mihajlo; Dežman, Rok; Ivanecz, Arpad; Potrč, Stojan; Bošnjak, Maša; Markelc, Boštjan; Kos, Bor; Miklavčič, Damijan; Gašljević, Gorana; Serša, Gregor | |
| Title | Intraoperative electrochemotherapy of colorectal liver metastases | |
| Type | članek | |
| Vol. and No. | Letnik 46, št. 9 | |
| Publication year | 2020 | |
| Volume | str. 1628-1633 | |
| ISSN | 0748-7983 - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology | |
| Language | eng | |
| Abstract | A previous pilot study proved the feasibility, safety and efficacy of electrochemotherapy in the treatment of colorectal liver metastases. The aim of this study was to evaluate long-term effectiveness and safety of electrochemotherapy in the treatment of unresectable colorectal liver metastases. Patients and methods In this prospective phase II study, patients with metachronous colorectal liver metastases were included. In all patients, at least one metastasis was unresectable due to its central location or a too-small future remnant liver volume. Patients were treated by electrochemotherapy using intravenously administered bleomycin during open surgery. Treated were 84 metastases in 39 patients. Local tumor control, progression-free survival and overall survival were evaluated. Results The objective response was 75% (63% CR, 12% PR). The median duration of the response was 20.8 months for metastases in CR and 9.8 months for tumors in PR. The therapy was significantly more effective for metastases smaller than 3%cm in diameter than for larger ones. There was no difference in response according to the metastatic location, i.e., metastases in central vs. peripheral locations. Progression-free survival was better in patients who responded well to electrochemotherapy compared to those metastases that had a partial response or progressive disease. However, there was no difference in overall survival, with a median of 29.0 months. Conclusions Electrochemotherapy has proven to be safe and effective in the treatment of colorectal liver metastases, with a durable response. It provides local tumor control that enables patients with unresectable metastases to receive further treatment modalities. | |
| Keywords | rak debelega črevesa in danke elektrokemoterapija elektroporacija bleomicin colorectal cancer electroporation electrochemotherapy bleomycin |