Author/Editor		Ruggi, Alessandro; Melchionda, Fraia; Sardi, Iacopo; Pavone, Rossana; Meneghello, Linda; Kitanovski, Lidija; Zadravec-Zaletel, Lorna; Farace, Paolo; Zucchelli, Mino; Scagnet, Mirko
Title		Toxicity and clinical results after proton therapy for pediatric medulloblastoma
Type		članek
Vol. and No.		Letnik 14, št. 11
Publication year		2022
Volume		str. 2747-1-2747-11
ISSN		2072-6694 - Cancers
Language		eng
Abstract		Medulloblastoma is the most common malignant brain tumor in children. Even if current treatment dramatically improves the prognosis, survivors often develop long-term treatment-related sequelae. The current radiotherapy standard for medulloblastoma is craniospinal irradiation with a boost to the primary tumor site and to any metastatic sites. Proton therapy (PT) has similar efficacy compared to traditional photon-based radiotherapy but might achieve lower toxicity rates. We report on our multi-centric experience with 43 children with medulloblastoma (median age at diagnosis 8.7 years, IQR 6.6, M/F 23/20; 26 high-risk, 14 standard-risk, 3 ex-infant), who received active scanning PT between 2015 and 2021, with a focus on PT-related acute-subacute toxicity, as well as some preliminary data on late toxicity. Most acute toxicities were mild and manageable with supportive therapy. Hematological toxicity was limited, even among HR patients who underwent hematopoietic stem-cell transplantation before PT. Preliminary data on late sequelae were also encouraging, although a longer follow-up is needed.
Keywords		pediatric brain tumors proton therapy medulloblastoma radiation otroški tumor na možganih protonska terapija meduloblastom obsevanje