Author/Editor		Skoblar Vidmar, Marija; Doma, Andrej; Smrdel, Uroš; Zevnik, Katarina; Studen, Andrej
Title		The value of FET PET/CT in recurrent glioma with a different IDH mutation status
Type		članek
Vol. and No.		Letnik 23, št. 12
Publication year		2022
Volume		str. 6787-1-6787-10
ISSN		1422-0067 - International journal of molecular sciences
Language		eng
Abstract		The evaluation of treatment response remains a challenge in glioma cases because the neuro oncological therapy can lead to the development of treatment-related changes (TRC) that mimic true progression (TP). Positron emission tomography (PET) using O-(2-[18F] fluoroethyl-)-L-tyrosine (18F-FET) has been shown to be a useful tool for detecting TRC and TP. We assessed the diagnostic performance of different 18F-FET PET segmentation approaches and different imaging biomarkers for differentiation between late TRC and TP in glioma patients. Isocitrate dehydrogenase (IDH) status was evaluated as a predictor of disease outcome. In our study, the proportion of TRC in IDH wild type (IDHwt) and IDH mutant (IDHm) subgroups was without significant difference. We found that the diagnostic value of static and dynamic biomarkers of 18F-FET PET for discrimination between TRC and TP depends on the IDH mutation status of the tumor. Dynamic 18F-FET PET acquisition proved helpful in the IDH wild type (IDHwt) subgroup, as opposed to the IDH mutant (IDHm) subgroup, providing an early indication to discontinue dynamic imaging in the IDHm subgroup.
Keywords		gliom obsevanje biološki označevalci napredovanje bolezni glioma radiation biomarkers true progression