Author/Editor | Jovanović, Marija; Jančič, Eva; Janić, Miodrag; Janež, Andrej; Lunder, Mojca | |
Title | Semaglutid - prvi peroralni agonist receptorjev GLP-1 za zdravljenje sladkorne bolezni tipa 2 | |
Translated title | Semaglutide - the first oral GLP-1 receptor agonist for the treatment of type 2 diabetes | |
Type | članek | |
Vol. and No. | Letnik 73, št. 3 | |
Publication year | 2022 | |
Volume | str. 231-240 | |
ISSN | 0014-8229 - Farmacevtski vestnik : strokovno glasilo slovenske farmacije | |
Language | slv | |
Abstract | Optimal glycemic control and multifactorial treatment are important for type 2 diabetes control. Non-pharmacological treatment is the mainstay of antihyperglycemic treatment, but it usually merits timely escalation of pharmacological intervention. One of the barriers to pharmacological treatment with GLP-1 receptor agonists was injectable treatment due to their polypeptide composition. In 2019, the first and only oral GLP-1 receptor agonist ‐ semaglutide, was introduced to clinical use. Due to structural modifications and technological processing of the tablet, the molecule is resistant to degradation in the acidic gastric envi- ronment and has a comparable effect as in the form of injectable treatment. Oral semaglutide was effective in improving glycemic control and redu- cing body weight, and proven for its cardiovascular safety. The present article describes the mechanism of action of GLP-1 receptor agonists, the development of oral semaglutide, dosing instructions and data from studies of its efficacy and safety. | |
Keywords | agonisti receptorjev GLP-1 antidiabetično zdravljenje peroralni semaglutid antihyperglycaemic treatment GLP-1 receptor agonists oral semaglutide |