Author/Editor		Tsermpini, Evangelia Eirini; Plemenitaš Ilješ, Anja; Dolžan, Vita
Title		Alcohol-induced oxidative stress and the role of antioxidants in alcohol use disorder
Type		članek
Vol. and No.		Letnik 11, št. 7
Publication year		2022
Volume		str. 1-33
ISSN		2076-3921
Language		eng
Abstract		Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still not fully elucidated. However, ethanol metabolism has been associated with increased oxidative stress through alcohol dehydrogenase, the microsomal ethanol oxidation system, and catalase metabolic pathways. We searched the PubMed and genome-wide association studies (GWAS) catalog databases to review the literature systematically and summarized the findings focusing on AUD and alcohol abstinence in relation to oxidative stress. In addition, we reviewed the ClinicalTrials.gov resource of the US National Library of Medicine to identify all ongoing and completed clinical trials that include therapeutic interventions based on antioxidants. The retrieved clinical and preclinical studies show that oxidative stress impacts AUD through genetics, alcohol metabolism, inflammation, and neurodegeneration.
Keywords		motnja uživanja alkohola odvisnost od alkohola oksidativni stres alcohol use disorder alcohol dependence oxidative stress