Author/Editor		Sharma, Kuldeepak; Erdani-Kreft, Mateja; Škufca Sterle, Mateja; Vasić, Darko
Title		Role of microbiome in inflammation during tuberculosis
Type		članek
Source		In: Microbiome in inflammatory lung diseases Singapore : Springer Nature Singapore : Imprint: Springer
Publication year		2022
Volume		str. 29-41
Language		eng
Abstract		The correlation between TB, which is one of the primary causes of chronic inflammatory disease and healthy microbiota in the community, is not sufficiently well known. The gut microbiota is critical for the regulation of inflammatory and immunological responses, and it has a substantial impact on the patient’s wellness. It was revealed that individuals’ lung mediated secretion and faecal samples had distinct tuberculosis-associated microorganisms, both prior and after the misleading effect of antibiotics. Numerous studies have demonstrated that isolated microbiota from patients’ faeces predicted the activation of pro-inflammatory immunological mechanisms, therefore establishing the value of the intestinal flora in tuberculosis therapy and prevention. The purpose of this study was to examine the microbiome and human defence system of TB patients. Collective data shows in this study that some intestinal microbiotas including anaerobes may influence the host, but additional mechanistic investigations are necessary. Therefore, we study the function of intestinal microbiota with the TB pathogenesis and may govern the immunity and inflammatory environment of host microbiota and their metabolites, as well as the pathways underlying host immunity.
Keywords		mikrobiota tuberkuloza kronične vnetne bolezni microbiota tuberculosis chronic inflammatory disease