| Author/Editor | Ratoša, Ivica; Skoblar Vidmar, Marija | |
| Title | Stereotactic radiosurgery for patients with breast cancer brain oligometastases | |
| Type | članek | |
| Vol. and No. | Letnik 26, št. 1 | |
| Publication year | 2021 | |
| Volume | str. 1-11 | |
| ISSN | 1507-1367 - Reports of Practical Oncology and Radiotherapy | |
| Language | eng | |
| Abstract | We sought to determine the clinical outcomes of patients with breast cancer (BC) who had undergone stereotactic radiosurgery (SRS) for a limited number of brain metastases (BM) and to identify factors influencing overall survival (OS) and local control. Material and methods: The records of 45 patients who underwent SRS for 72 brain lesions were retrospectively evaluated. Statistics included the chi-squared test, Kaplan-Meier method, and the multivariate Cox model. Results: The median number of treated BM was 2 (range 1%10). Median OS from BM diagnosis and post-SRS were 27.6 [95% confidence interval (CI): 14.8%40.5) and 18.5 months (95% CI: 11.1%25.8), respectively. One-year and two-year survival rates after BM diagnosis were 55% and 41%, respectively. In a univariate analysis, the Luminal-B-human-epidermalgrowth-receptor-positive (HER2+) subtype had the longest median OS at 39.1 months (95% 2 CI: 34.1%44.1, p = 0.004). In an adjusted analysis, grade 2 [hazard ratio (HR): 0.1; 95% CI: 0.1%0.6, p = 0.005), craniotomy (HR: 0.3; 95% CI: 0.1%0.7; p = 0.006), and % 2 systemic therapies received (HR: 0.3; 95% CI: 0.1%0.9, p = 0.028) were associated with improved OS. One-year and two-year intracranial progression-free survival rates were 85% and 63%, respectively. Four factors for a higher risk of any intracranial recurrence remained significant in the adjusted analysis, as follows: age < 50 years (HR: 4.2; 95% CI: 1.3%36.3; p = 0.014), grade 3 (HR: 3.7; 95% CI: 1.1%13.2; p = 0.038), HER2+ (HR: 6.9; 95% CI: 1.3%36.3; p = 0.023), and whether the brain was the first metastatic site (HR: 4.7; 95% CI: 1.6%14.5; p = 0.006). Conclusion: Intrinsic BC characteristics are important determinants for both survival and intracranial control for patients undergoing SRS for oligometastatic brain disease. | |
| Keywords | rak dojke metastaze v možganih stereotaktična radiokirurgija molekularni podtip breast cancer brain metastases stereotactic radiosurgery molecular subtype |