Author/Editor		LoPresti, Elena; Nuzzo, Domenico; Mahmeed, Wael Al; Al-Rasadi, Khalid; Al-Alawi, Kamila; Banach, Maciej; Banerjee, Yajnavalka; Ceriello, Antonio; Cesur, Mustafa; Janež, Andrej
Title		Molecular and pro-inflammatory aspects of COVID-19
Type		članek
Publication year		2022
Volume		str. str.
ISSN		1879-260X
Language		eng
Abstract		Obesity, type 2 diabetes (T2DM), hypertension (HTN), and Cardiovascular Disease (CVD) often cluster together as “Cardiometabolic Disease” (CMD). Just under 50 % of patients with CMD increased the risk of morbidity and mortality right from the beginning of the COVID-19 pandemic as it has been reported in most countries affected by the Sars-CoV2 virus. One of the pathophysiological hallmarks of COVID-19 is the overactivation of the immune system with a prominent IL-6 response, resulting in severe and systemic damage involving also cytokines such as IL2, IL4, IL8, IL10, and interferon-gamma were considered strong predictors of COVID-19 severity. Thus, in this mini-review, we try to describe the inflammatory state, the alteration of the adipokine profile, and cytokine production in the obese state of infected and not infected by SARS-CoV2 patients with the final aim to find possible influences of COVID-19 on CMD and CVD. The immunological-based discussion of the molecular processes could inspire the study of promising targets for managing CMD patients and its complications during COVID-19.
Keywords		COVID-19 cardiometabolic health inflammation COVID-19 kardiometabolično zdravje vnetje