Author/Editor		Madorran, Eneko; Stožer, Andraž; Bevc, Sebastjan; Maver, Uroš
Title		In vitro toxicity model
Type		članek
Vol. and No.		Letnik 20, št. 2
Publication year		2020
Volume		str. 157-168
ISSN		1840-4812 - Bosnian journal of basic medical sciences / Udruzenje basicnih mediciniskih znanosti = Association of Basic Medical Sciences
Language		eng
Abstract		The Centers for Disease Control and Prevention (CDC) provides extensive data that indicate our need for drugs to maintain human population health. Despite the substantial availability of drugs on the market, many patients lack specific drugs. New drugs are required to tackle this issue. Moreover, we need more reliable models for testing drug toxicity, as too many drug approval failures occur with the current models. This article briefly describes various approaches of the currently used models for toxicity screening, to justify the selection of in vitro cell-based models. Cell-based toxicity models have the best potential to reliably predict drug toxicity in humans, as they are developed using the cells of the target organism. However, currently, a large gap exists between in vitro cell-based approach to toxicity testing and the clinical approach, which may be contributing to drug approval failures. We propose improvements to in vitro cell-based toxicity models, which is often an insight approach, to better match this approach with the clinical homeostatic approach. This should enable a more accurate comparison of data between the preclinical as well as clinical models and provide a more comprehensive understanding of human physiology and biological effects of drugs.
Keywords		toxicity models cell-based models in vitro physiological models bioanalysis drug approval toxicity testing toxicity prediction drug toxicity preclinical research