Author/Editor		Oražem, Miha; Draulans, Cédric; Spaas, Mathieu; Cutsem, Eric Van; Debecker, Marina; Meerleer, Gert De; Tejpar, Sabine; Dekervel, Jeroen; Haustermans, Karin
Title		A fatal wound complication following sequential anti-angiogenesis, immune checkpoint inhibition and ultra-hypofractionated radiotherapy
Type		članek
Vol. and No.		, št. Vol. 14
Publication year		2021
Volume		str. 1121‐1125
ISSN		1865-7265 - Clinical journal of gastroenterology
Language		eng
Abstract		Purpose: Multimodality treatments combining radiotherapy, immune therapy and/or targeted therapy are under heavy investigation. Promising data from clinical trials are emerging, nevertheless unexpected interactions and adverse events should not be overlooked. Case presentation: Here we present a case study of a patient with metastatic colon adenocarcinoma treated sequentially with a chemotherapy/targeted therapy combination, immune checkpoint inhibitors and ultra-hypofractionated radiotherapy. After radiation treatment, the patient developed extensive posterior abdominal wall wounds coinciding with regression of the irradiated metastatic tumour mass and marked elevation of the inflammation parameters. Conclusion: This case represents an unusual fatal wound complication after palliative ultra-hypofractionated radiotherapy. Further research into synergistic effects of sequential radiotherapy and anti-angiogenesis therapy may provide an advantage in anticipating severe sequelae.
Keywords		radioterapija imunski zaviralci kontrolnih točk antiangiogeneza klinični primeri radiotherapy immune checkpoint inhibition anti-angiogenesis case report