| Author/Editor | Jensterle Sever, Mojca; Ferjan, Simona; Ležaič, Luka; Sočan, Aljaž; Goričar, Katja; Zaletel, Katja; Janež, Andrej | |
| Title | Semaglutide delays 4-hour gastric emptying in women with PCOS and obesity | |
| Type | članek | |
| Publication year | 2022 | |
| Volume | str. str. | |
| ISSN | 1462-8902 - Diabetes, obesity and metabolism | |
| Language | eng | |
| Abstract | Context: Semaglutide could contribute to reduced energy intake and weight loss by delaying gastric emptying (GE). However, the evidence for notable effects of semaglutide is inconclusive and compromised by the use of indirect methodology. Objective: to evaluate the effect of once-weekly subcutaneous semaglutide 1.0 mg on late digestive period of GE after ingestion of a standardized solid test meal by using technetium scintigraphy, the reference method for this purpose. Design: We conducted single-blind, placebo-controlled trial with 20 obese women with PCOS (average age 35 (32.3-40.8) years), BMI 37 (30.7-39.8) kg/m2 ) randomized to s.c semaglutide 1.0 mg QW (S) or placebo (P) for 12 weeks. GE was assessed after ingestion of [99mT c] colloid in pancake labeled with radiopharmaceutical by scintigraphy using sequential static imaging and dynamic acquisition at baseline and at week 13. Estimation of GE was obtained by repeated imaging of remaining [99mT c] activity (RA) at fixed time intervals over 4 hours after ingestion. Results: From baseline to the study end, semaglutide increased the estimated retention of gastric contents by 3.5% at the 1st hour, 25.5% at 2nd , 38.0% at 3rd and 30.0% at the 4th hour after ingestion of the radioactively labeled solid meal. Four hours after ingestion, semaglutide retained 37% of solid meal in the stomach compared to no gastric retention in P group (p=0.002). Half time (T1/2 ) was significantly longer in S as compared to P (171 min vs 118 min, (p<0.001). Conclusion: Semaglutide markedly delayed 4-hour GE in women with PCOS and obesity. This article is protected by copyright. All rights reserved. | |
| Keywords | PCOS debelost semaglutid PCOS obesity semaglutide |