Author/Editor		Šmuc, K; Štalc, M
Title		Vpliv menstruacijskega ciklusa na teste hemostaze
Translated title		The effect of menstrual cycle on hemostatic tests
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 34, št. 2
Publication year		1995
Volume		str. 167-86
Language		slo
Abstract		We studied 31 healthy volunteers with a normal menstrual cycle, who were divided according to their age into a group of younger women and a group of premenopausal women. During four phases parts of the menstrual cycle, blood samples were drawn for determination of serum fibrinogen, tissue plasminogen activator (t-PA) antigen, t-PA activity, t-PA inhibitor (PAI-1) antigen, PAI-1 activity, and euglobulin clot lysis. Blood samples for determination of serum estradiol and progesterone levels were obtained during the follicular and luteal phase of the menstrual cycle. Then values of fibrinolytic parameters for individual menstrual cycle phases were compared within each group. In young women, PAI-1 activity determined during the luteal phase differed significantly from PAI-1 activity measured during the follicular and ovulatory phase. As for other fibrinolytic parameters, no significant changes were found in either group. Statistically significant differences were established between young and premenopausal women as concerns their serum t-PA antigen, t-PA activity, PAI-1 antigen, PAI-1 activity and euglobulin clot lysis in all phases of the menstrual cycle. During the luteal phase, there was a correlation between serum fibrinogen and progesterone levels in the whole group and in the group of young women, while the premenopausal group showed a significant increase in serum estradiol which correlated with a decrease in PAI-1 antigen and PAI-1 activity. Both groups demonstrated a correlation between increased serum progesterone and elevated t-PA activity during the luteal phase. The results of this study stress the importance of analysing hemostatic parameters on exactly determined days of the menstrual cycle. In conclusion, premenopausal women showed lesser fibrinolytic activity than young females.(trunc.)
Descriptors		MENSTRUAL CYCLE FIBRINOLYSIS BLOOD COAGULATION TESTS ALTEPLASE PLASMINOGEN ACTIVATOR INHIBITOR 1 ESTRADIOL PROGESTERONE LIPIDS FIBRINOGEN