Author/Editor		Coer, A
Title		Imunohistokemični označevalci celičnega razmnoževanja
Translated title		Immunohistochemical markers of cellular proliferation
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 34, št. 2
Publication year		1995
Volume		str. 203-10
Language		slo
Abstract		The author undertook the study of cellular proliferation, particularly in human tumours, in order to test the hypothesis that the quantification of this fundamental biological process can provide objective information about the clinical course and prognosis of cancer. Recently, immunohystochemical staining with antibodies against proliferation-associated antigen has been used for determining the growth fraction. Anti-PCNA and Ki-67 are the most frequently employed markers. PCNA is DNA polymerised auxiliary protein. During S phase of the cell cycle nuclei of the cells are PCNA positive. Antibody Ki-67 recognizes nuclear antigens, which are present solvely in proliferating cells and are absent in resing cells during Go phase. The paper gives an overview of the principal biological characteristics of immunohistochemical markers anti-PCNA and Ki-67, and presents their applications in pathology and the author's experience with these markers.
Descriptors		NEOPLASMS PROLIFERATING CELL NUCLEAR ANTIGEN IMMUNOHISTOCHEMISTRY PROGNOSIS GENES, RAS CELL DIVISION