| Author/Editor | Pivac, N; Dobovišek, J; Bagatin, J; Gros-Furek, V; Rumboldt, Z; Janežić, A; Kveder, R; Sjerobabski, V; Šimunić, M; Sardelić, S | |
| Title | Usporedba amlodipina i retard pripravka nifedipina u liječenju arterijske hipertenzije | |
| Translated title | A comparsion of amlodipine vs. sustained-release nifedipine in essential hypertension | |
| Type | članek | |
| Source | Liječ Vjesn | |
| Vol. and No. | Letnik 115 | |
| Publication year | 1993 | |
| Volume | str. 356-9 | |
| Language | cro | |
| Abstract | The efficacy and acceptability of amlodipine (5-10 mg o.d.) and sustained-release nifedipine (20-40 mg b.i.d.) were compared in a multicenter, double-blind clinical trial. After a two-week placebo period, 71 essential hypertensives of both sexes, aged 51.7 +-8.5 years, having diastolic blood pressure of 95-114 mm Hg were randomly allocated to either amlodipine 5 mg once daily (group A) or nifedipine 20 mg twice daily (group B). With respect to the blood pressure response, the initial dose was doubled after two weeks. No significant differences in blood pressure recorded at baseline and at the end of the placebo period were demonstrated. A significant reduction in both systolic and diastolic blood pressures in the supine position was observed already two days after the start of treatment. In the group A it decreased from 163.2+-21.4/102.7+-8.5 to 155.7+-20.7/98.2+-8.9 mm Hg (p less than 0.05) and in the group B from 160.5+-16.2/1000.5+-12.2 to 152.2+-17.0/95.4+-9.5 mm Hg (p less than 0.05). The similar changes of blood pressure were observed in the standing position, as well. At the end of the study, the overall reduction of the supine diastolic blood pressure was 12.5 percent in the group A versus 5.2 percent in the group B (p less than 0.05). In the standing position, amplodine decreased diastolic blood pressure by 8.8 percent and nifedipine by 6.4 percent (p less than 0.05). Furthermore, amlodipine decreased the the standing diastolic blood pressure to a greater extent (8.8 percent versus 6.4 percent; p less than 0.05) than nifedipine. A 24-hour maintenance of the achieved goal blood pressure was confirmed in 8 patients from each group, using a continued ambulatory monitoring. An increase in heart rate for 4.1 percent (A) and 5.2 percent (B), respectively, was found at the beginning of treatment, which did not last until the end of the study.(trunc.) | |
| Descriptors | HYPERTENSION AMLODIPINE NIFEDIPINE ADULT MIDDLE AGE AGED MULTICENTER STUDIES DOUBLE-BLIND METHOD BLOOD PRESSURE |