Author/Editor		Kosmina, B; Lavrenčič, A
Title		Debelina intime in medije karotidnih arterij pri mladostnikih z družinsko hiperholesterolemijo
Translated title		Carotid intima-media thickness in young patients with familial hypercholesterolemia
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 33, št. 4
Publication year		1994
Volume		str. 463-90
Language		slo
Abstract		Familial hypercholesterolemia, an inheritable metabolic disorder, is the most pow- erful risk factor for the accelerated atheroscle- rosis. Mean intima-media thickness of carotid arteries was determined with B-mode ultra- sonography in 28 young patients with familial hypercholesterolemia and in 28 normolipemic subjects. Serum lipids, lipoprotein(a), glucose, coagulation and fibrinolytic parameters were determined. Mean intima-media thickness was significantly greater in patients with familial hyper- cholesterolemia than in controls (0.71 +- 0.15 vs. 0.4 +- 0.08mm, p < 0.0001). In all subjects together mean intima-media thickness was pos- itively correlated with total cholesterol, low-den- sity lipoprotein cholesterol, triglycerides, and systolic blood pressure. In patients with famil- ial hypercholesterolemia mean intima-media thickness was positively correlated with age and systolic blood pressure, while in controls it was correlated with systolic blood pressure, body weight and height, triglycerides and tissue plasminogen activator antigen and it was greater in males than females. Multiple regression analy- sis identified the group of patients with familial hypercholesterolemia, higher triglycerides and age as the independent determinants of IMT in all subjects together, while in controls these determinants were sex, age and triglyceride level.
Descriptors		ATHEROSCLEROSIS HYPERCHOLESTEROLEMIA, FAMILIAL RISK FACTORS CAROTID ARTERIES TUNICA INTIMA TUNICA MEDIA ADOLESCENCE