Author/Editor		Bourgeois, CA; Kokalj-Vokač, N; Dutrillaux, AM; Poisson, M; Delattre, JY; Vega, F; Malfoy, B; Dutrillaux, B
Title		Caracterisation par hybridation in situ des remaniements chromosomiques dans un glioblastome
Type		članek
Source		Bull Cancer
Vol. and No.		Letnik 81
Publication year		1994
Volume		str. 360-5
Language		fre
Abstract		Chromosomal rearrangements in a glioblastoma; site specificity? In a case of glioblastoma, the following karyotype was determined: 47, X, -Y + der(1) t(1;9)(p21;p23), t(1;9)(p21;p23), +3, +7, der(9) t(Y;9)(q11;p21), -13, t(13;16)(p13, p11), dell(14)(q11q22). Classical satellite DNAs are mainly located in chromosomes 1,9, 15, 16 and Y. Because, most of these chromosomes were implicated in the rearrangements, a detailed cytogenetic study was undertaken. This study included in situ hybridization of the satellite and alphoid DNAs of chromosomes 1, 9, 16 and Y combined with various chromosome banding methods (DA-DAPI, quinacrine mustard and R-banding). The data obtained, demonstrated that the breakpoints were always located outside the areas containing the satellite and alphoid DNAs. The situation observed here differs from that reported in breast cancers for which a high proportion of the breakpoints than those implicated in brest cancers. Thus, in cancers, chromosomal instabilities may result from several mechanisms.
Descriptors		GLIOBLASTOMA KARYOTYPING CHROMOSOME FRAGILE SITES DNA, SATELLITE CHROMOSOME ABNORMALITIES CHROMOSOME BANDING IN SITU HYBRIDIZATION