Author/Editor		Vogler, Andrej
Title		Inzulinu podobni rastni faktor (IGF 1) v foliklovi tekočini pri bolnicah z nizkim odzivom na stimulacijo ovulacije v postopku zunajtelesne oploditve
Translated title		Follicular fluid insulin like growth factor-i in "lov-responders" undergoing ivf treatment
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1996
Volume		str. 67
Language		slo
Abstract		Background. Ovulation induction is one of the major prognostic factors that determines the number of retrieved oocytes, quality and vaibility of embryos. About 10 to 15% of patients in IVF treatment, recognised as "low-responders", do not respond to ovarian stimulation by exogenous gonadotrophin administration with adequate number of mature follicles and oocytes. Well establishes causes for low ovarian response are the following: extensive pelvic adhesions due to inflammation, endometriosis, radical adnexal surgery, obesity and ageing. Quite often low ovarian response could not be ascribed to any known causes. Insulin like growth factor (IGF-I), stimulating mitosis and cytodifferentiation in many systems, has an important role in folliculogenesis. There is an increasing body of evidence that IGF-I plays a role in cyclic follicular development. It amplifies gonadotrophin action on ovary, manifested as increase aromatase activity, higher production of estradiol (E2), progesterone and luteinnizing hormone receptors. The role of IGF-I in low ovarian response has not been clarified yet. To put a little light on that, we tried to answer the hypothesis that serum and follicular fluid concentrations of IGF-I in "low-responders" are different than in patients responding optimally to ovarin stimulation in IVF procedure. Methods. A group of 40 randomly selected "low-responders" (group "A") was compared to a group of 120 normal responding patients (group "B") in IVF treatment. In both groups the following parameters were studied: anthropometric parameters, indications for the IVF, ovarian response to ovarian stimulation, pregnancy rate, IGF-I and E2, concentrations in follicular fluid and serum. Statistical differences and correlations between the observed parameters were analysed. Results. Abstract truncated at 2000 characters.
Descriptors		OVULATION INDUCTION INSULIN-LIKE GROWTH FACTOR I FERTILIZATION IN VITRO EMBRYO TRANSFER BODY MASS INDEX ESTRADIOL MENOTROPINS OOCYTES FOLLICULAR FLUID