Author/Editor		Kuzman, T; Kikelj, D
Title		Stereoizomerija karbapenemov in njen vpliv na biološko učinkovitost
Translated title		Stereoisomerism of carbapenems and its influence on biological activity
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 47, št. 1
Publication year		1996
Volume		str. 17-29
Language		slo
Abstract		Carbapenems are broad spectrum antibiotics possessing potent antibacterial activities against Gram-positive and Gram-negative bacteria, some of them also exhibit inhibitory activity against bacterial beta-lactamases. Thienamycin produced by Streptomyces cattleya represents a lead compound for development of new carbapenem antibiotics. The absolute configuration at positions 5, 6 and 8 of carbapenem nucleus influences the antibacterial activity, stability and also inhibitory activity against bacterial beta-lactamases. Introduction of 1-beta-methyl substituent to the carbapenem nucleus increases metabolical stability (stability against renal dehydropeptidase-1) and antibacterial activity, including activity against Pseudomonas sp. and MRSA in some cases.
Descriptors		CARBAPENEMS STEREOISOMERS MICROBIAL SENSITIVITY TESTS THIENAMYCINS