Author/Editor | Srčič, S; Planinšek, O; Sollner, M; Pečar, S | |
Title | Termične lastnosti N-(7-oksoacil)-L-alanil-D-izoglutaminov | |
Translated title | Thermal behaviour of N-(7-oxoacyl)-L-alanyl-D-isoglutamines | |
Type | članek | |
Source | Farm Vestn | |
Vol. and No. | Letnik 47, št. 1 | |
Publication year | 1996 | |
Volume | str. 55-62 | |
Language | slo | |
Abstract | Dezmuramyidipeptides N-(7-oxoacyl)-L-alanyl-D-isoglutamines are substances with similar effects on imune system as natural imunomodulator N-ace-tylmuramyldipeptide. In investigated molecules lipophilicity was changed by incorporation of methylene groups in acyl part. Influence of such structural change of N-(7-oxoacyl)-L-alanyl-D-isoglutamines on their melting point and melting enthalpy was studied. Decrease of melting point and melting enthalpy with increased lenght of alkyl chain was found. metastable polymorphic structures and thermal instability of some analogues were also discovered. | |
Descriptors | ACETYLMURAMYL-ALANYL-ISOGLUTAMINE HEAT TEMPERATURE |