Author/Editor		Kristl, J; Allemann, E; Gurny, R
Title		Formulation and evaluation of zinc-phthalocyanine loaded poly(D,L-lactic acid) nanoparticles
Translated title		Oblikovanje in vrednotenje nanodelcev poli(D,L-mlečne kisline) z vključenim cinkovim ftalocianinom
Type		članek
Source		Acta Pharm
Vol. and No.		Letnik 46, št. 1
Publication year		1996
Volume		str. 1-12
Language		eng
Abstract		To provide a colloidal carrier system loaded with zinc-phthalocyanine (ZnPc) for photodynamic therapy biodegradable poly(D,L-lactic acid) (PLA) nanoparticles were prepared by the salting-out method and solvent diffusion method. For appropriate nanoparticle features and loading capacity, the PLA concentration in the organic phase, the protective hydrocolloid concentration in the aqueous phase, and the organic/aqueous phase ratio played a predominant role. The nanoparticle formation was dependent on the rate of diffusion of the organic solvent into the aqueous phase, thus influencing polymer precipitation. The loading capacity and entrapment efficiency were high. ZnPc-loaded PLA nanoparticles were also purified and freeze-dried. In order to obtain well redispersible PLA nanoparticles, the presence of additives such as trehalose, lactose or glucose was of great importance; the freezing temperature played a minor role. PLA nanoparticles have a regular spherical shape with a mean diameter of 300 nm or less.
Descriptors		DRUG CARRIERS PHOTOSENSITIZING AGENTS PHTHALIC ACIDS ZINC PHOTOCHEMOTHERAPY LACTATES